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Organocatalytic Asymmetric Michael Addition/Carbon‐Carbon Bond Cleavage of Trifluoromethyl α‐Fluorinated gem‐Diols to Nitroolefins |
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| Authors: | Ibrayim Saidalimu Xiang Fang Wenwen Lv Xueyan Yang Xiaopeng He Jingyuan Zhang Fanhong Wu |
| Abstract: | A new organocatalytic asymmetric Michael addition reaction by cleavage of carbon‐carbon bonds through a mild release of trifluoroacetate has been developed. The reported method generates the decarboxylated γ‐nitro‐α‐fluorocarbonyl products with excellent enantioselectivies (up to 98% ee) and good diastereoselectivies (up to 20:1 dr). |
| Keywords: | asymmetric Michael addition carbon‐carbon bond cleavage thiourea catalysts trifluoroacetate release trifluoromethyl α ‐fluorinated gem‐diols |