Interaction of richlocain with some linear and crosslinked polymers

The interaction of local anesthetic drug richlocain with linear polyacrylic acid and crosslinked sodium polyacrylate, linear and crosslinked acrylic acid-Schiff base copolymers has been investigated. The compositions of forming polymer-drug complexes were determined. The influence of external factors such as pH, ionic strength, temperature and thermodynamic quality of solvent on the stability of these complexes was studied. The kinetics and activation energy of drug release from the gel matrix has been evaluated.