Comparison of high dose rate, low dose rate, and high dose rate fractionated radiation for optimizing differences in radiosensitivities in vitro |
| |
Authors: | RC Wilkins CE Ng GP Raaphorst |
| |
Affiliation: | Institut für Pharmazie und Lebensmittelchemie. Julius-Maximilians-Universit?t Würzburg, mueller@pharmazie.uni-wuerzburg.de |
| |
Abstract: | In an attempt to clarify the biological nature of a human endogenous retrovirus (HERV), HERV-R, which is a single-copy type of HERVs and is conserved as a full-length viral sequence, the expression of HERV-R mRNA in normal autopsied systemic organs was examined by Northern blot analysis. The expression showed different levels among individuals, with the adrenal glands expressing the highest level of HERV-R among all organs tested, except for the placenta. In various adrenal tumors, HERV-R was expressed at high levels in all cortical adenomas but less so in pheochromocytomas. In situ hybridization revealed the expression of HERV-R to be localized in all layers of the adrenal cortex, but not in the medulla. This high-level expression of HERV-R in the adrenal cortex may possibly relate to differentiation and/or steroid production by adrenocortical cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|