Glycerolipids as selective thrombin inhibitors from the fungus Stereum hirsutum |
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| Authors: | Doljak Bojan Cateni Francesca Anderluh Marko Procida Giuseppe Zilic Jelena Zacchigna Marina |
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| Affiliation: | a Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Sloveniab Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Trieste, Trieste, Italyc Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Sloveniad DEMREP, University of Trieste, Trieste, Italy |
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| Abstract: | A dry extract of Stereum hirsutum exhibited a significant inhibitory activity on thrombin (34%). A bioassay oriented fractionation of the extract of Stereum hirsutum has led to the isolation of two active fractions. On the basis of spectroscopic data, chemical reactions, and GC-MS analysis, complex mixtures of diacylglycerophospholipids (DAGPs) and diacylglycerols (DGs) have been isolated and identified. Docking studies suggest that some isolated compounds could bind to the thrombin active site in a similar manner as previously reported phosphonate thrombin inhibitors. |
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| Keywords: | Thrombin Inhibition Mushrooms Extract Screening Docking |
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