Assessment of biocompatibility of chronically implanted polyimide and platinum intrafascicular electrodes |
| |
Authors: | Lago Natalia Yoshida Ken Koch Klaus P Navarro Xavier |
| |
Affiliation: | Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autónoma de Barcelona, E08193 Bellaterra, Spain. |
| |
Abstract: | Longitudinal intrafascicular electrodes (LIFEs) are electrodes designed to be placed inside the peripheral nerve to improve stimulation selectivity and to increase the recording signal-to-noise ratio. We evaluated the functional and morphological effects of either Pt wire LIFEs or polyimide-based thin-film LIFEs implanted in the rat sciatic nerve for 3 mo. The newly designed thin-film LIFEs are more flexible, can be micromachined and allow placement of more active electrode sites than conventional Pt LIFEs. Functional results at 1 mo indicated an initial decline in the nerve conduction velocity and in the amplitude of muscle responses, which recovered during the following 2 mo towards normal values. Morphological results showed that both types of LIFEs induced a mild scar response and a focal but chronic inflammatory reaction, which were limited to a small area around the electrode placed in the nerve. Both types of LIFEs can be considered biocompatible and cause reversible, minimal nerve damage. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|