| 纳滤分离提取谷氨酰胺过程的研究 |
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| 引用本文： | 李书良,李春,高毅,王晓琳,曹竹安.纳滤分离提取谷氨酰胺过程的研究[J].高校化学工程学报,2003,17(6):715-719. |
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| 作者姓名： | 李书良 李春 高毅 王晓琳 曹竹安 |
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| 作者单位： | 清华大学化学工程系生物化工研究所,北京,100084 |
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| 基金项目： | “十五”国家科技攻关课题(2001BA708B02-05)。 |
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| 摘 要： | 对发酵液中的谷氨酰胺提取进行了采用纳滤膜分离技术的尝试，并对谷氨酰胺和谷氨酸混合溶液的纳滤分离进行了理论分析。研究了不同pH条件下发酵液中谷氨酰胺和谷氨酸在纳滤过程中的透过特性，并考察了纳滤过程中氨基酸的透过特性随压力和浓度的变化。结果表明：当发酵液pH=7，谷氨酰胺浓度为1％时，纳滤膜分离谷氨酰胺的提取总收率可达到65％以上。
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| 关 键 词： | 纳滤膜分离 氨基酸 谷氨酰胺 发酵液 |
| 文章编号： | 1003-9015(2003)06-0715-05 |
| 修稿时间： | 2002年11月20 |
Separation of L-Glutamine from Broth by Nanofiltration |
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| LI Shu-liang,LI Chun,GAO Yi,WANG Xiao-lin,CAO Zhu-an.Separation of L-Glutamine from Broth by Nanofiltration[J].Journal of Chemical Engineering of Chinese Universities,2003,17(6):715-719. |
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| Authors: | LI Shu-liang LI Chun GAO Yi WANG Xiao-lin CAO Zhu-an |
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| Abstract: | The nanofiltration (NF) was applied in the separation and extraction of L-glutamine from the fermentation broth. The theoretical and experimental retention of L-glutamine and L-glutamic acid solution were studied in different pH value. The permeation behavior of L-glutamine and L-glutamic acid in broth were investigated under different pH value, pressure and concentration of L-glutamine. It is showed that the extraction yield of the whole process is estimated over 65% when the concentration of L-glutamine and pH are 1% and 7 in broth, respectively. |
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| Keywords: | nanofiltration membrane separation amino acid L-glutamine broth |
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