4-乙酰氨基环己醇的顺反立体异构化工艺

以Reney-Ni为催化剂，对4－乙酰氨基环己醇加氢和脱氢反应进行研究，它能促进4－乙酰氨基环己醇立体异构化反应。对反应溶剂，添加剂，H2保护和H2压力等影响因素进行了考察。结果表明：在添加剂AN－1和常压氢保护气氛存在下，以水为溶剂，在回流温度下反应6h,Raney-Ni对顺式反式异构化反应具有较好的效果。反应主要受热力学控制。当以顺反比66：34的4－乙酰氨基环己醇为原料时，平衡产物中，反式异构体可占总醇分离的66％－68％。Raney-Ni在使用过程中，具有良好的催化活性和稳定性。平衡良好的催化活性和稳定性。平衡产物经浓缩结晶，可获得以固体原料计38％以上的较纯（93％）反式异构体。

Cis-trans Epimerizatin Technology of N-(4-hydroxycyclo hexyl) Acetamide

Raney-Ni was adopted as catalyst for dehydrogenation and hydrogenation of N-(4-hydroxycyclohexyl) acetamide, it could improve the cis-trans epimerization of N-(4-hydroxycyclohexyl) acetamide. The effects of solvent, addition agent, H2 protective atmosphere and agent H2 pressure on catalytic reaction were investigated. The study indicate that with addition AN-1 and protective atmosphere of hydrogen, water adopted as solvent, reaction at refluxing temperature in 6h, Raney-Ni appeared to have a fairly good performance for the epimerization of N-(4-hydroxycyclohexyl) acetamide. The major reaction is controlled by thermodynamical equilibrium. When N-(4-hydroxycyclohexyl) acetamide with the cis-trans ratio 66:34 as start material, it can make up 66 to 68 percent trans isomer of total cis and trans isomers in the equilibrium solution through epimerization. Raney-Ni had an excellent catalytic activation and stability in use. By means of concentration and crystallization, an overall yield of more than 38 percent of pure trans isomer (93%) can be obtained from equilibrium products.