A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives |
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| Authors: | R Saladino MC Danti E Mincione C Crestini AT Palamara P Savini S Marini M Botta |
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| Affiliation: | Dipartimento Agrochimico Agrobiologico, Università degli studi di Viterbo La Tuscia, Italy. Saladino@unitus.it |
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| Abstract: | Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6-trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl-4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1(Sendai) virus replication. |
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