| 高效液相色谱法测定吡罗昔康片的含量 |
| |
| 引用本文： | 张宏祥,刘燕. 高效液相色谱法测定吡罗昔康片的含量[J]. 现代科学仪器, 2011, 0(2): 104-105 |
| |
| 作者姓名： | 张宏祥 刘燕 |
| |
| 作者单位： | 安徽省池州市食品药品检验所,安徽,池州,247000 |
| |
| 摘 要： | 目的探讨吡罗昔康片含量测定的方法。方法采用GL Sciences Inertsil ODS-SP（5p-m，250×4．6mm）色谱柱，以乙腈一磷酸盐缓冲液（取磷酸氢二钠7．15g，加水溶解成1000mL，用20％柠檬酸溶液调节pH值为5．0）（40：60）为流动相，检测波长为358nm，柱温为55℃，流速为1．0mL·rnin^-1。结果吡罗昔康在21．26～106．30mg·L＾－1“范围内进样量与峰面积呈良好线性关系（r=0．9999），平均回收率为99．68％（n=6），gSD为0．88％。结论HPLC法测定吡罗昔康片的含量，专属性强，结果准确可靠。
|
| 关 键 词： | 高效液相色谱法 吡罗昔康 含量测定 |
Determination of Piroxicam Tablets by High Performance Liquid Chromatography |
| |
| Zhang Hongxiang,Liu Yan. Determination of Piroxicam Tablets by High Performance Liquid Chromatography[J]. Modern Scientific Instruments, 2011, 0(2): 104-105 |
| |
| Authors: | Zhang Hongxiang Liu Yan |
| |
| Affiliation: | Zhang Hongxiang,Liu Yan(Chizhou Institute for Food and Drug Control,Chizhou,Anhui 247000) |
| |
| Abstract: | A method determining the piroxicam tablets is explored. Methods： GL Sciences Inertsil ODSSP（51ma, 250x4.6mm）column was used. The mobile phase was acetonitrile-phosphate buffer solution （disodium hydrogen phosphate 7.15g, dissolved in water into 1000mL, adjusted with 20% citric acid solution, pH 5.0） （40：60）. The detection wavelength was 358nm.The column temperature was 35℃and the flow rate was 1.0mL-min^-1. Results： Piroxieam in the 21.26-106.30 mg·L^-1 within the sample volume and the peak area showed good linearity （r = 0.9999）.The average recovery rate was 99.68%（n=6）, and RSD was 0.88%. Conclusion： The determination of piroxicam tablets by HPLC is specific, accurate and reliable. |
| |
| Keywords: | High performance liquid chromatography Piroxicam Determination |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
