高效液相色谱法测定化妆品中防晒剂奥克立林含量的不确定度评定

通过对化妆品能力验证样品中奥克立林含量检测的不确定度评定,分析影响防晒剂定量检测的相关因素。根据《化妆品安全技术规范》(2015年版)中15种防晒剂的高效液相色谱测定法,按照JJF 1135-2005《化学分析测量不确定度评定》和JJF 1059.1-2012《测量不确定度评定与表示》中的有关规定,建立测定奥克立林的不确定度数学模型,并对不确定度来源进行分析和评定。结果表明,当化妆品中奥克立林含量为0.843%时,拓展不确定度为0.026%(k=2)。不确定度的主要来源为标准溶液的配制及工作曲线的拟合。

Uncertainty Evaluation for Determination of Octocrilene Derivatives as Sunscreen Agent in Cosmetics by High Performance Liquid Chromatography

The uncertainty of content detection of Octocrilene derivatives as sunscreen agent in cosmetics capability test sample was analyzed and related factors affecting the quantitative detection of sunscreen agent were analyzed. According to the high performance liquid chromatography for the determination of 15 sunscreen agents in Safety and Technical Standards for Cosmetics (2015 Edition), in accordance with JJF 1135-2005 Evaluation of Uncertainty in Chemical Analysis Measurement and JJF 1059.1-2012 Evaluation and Expression of Uncertainty in Measurement, a mathematical model for the determination of Octocrilene was established, and the source of uncertainty was analyzed and evaluated. The results showed that the content of Octocrilene in cosmetics was 0.843% and the relative expanded uncertainty of measurement result was 0.026% (k=2). The main uncertainty came from the configuration of standard solution and the fitting of calibration curve.