Joint immobilization inhibits spontaneous hyaline cartilage regeneration induced by a novel double-network gel implantation |
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Authors: | Arakaki Kazunobu Kitamura Nobuto Kurokawa Takayuki Onodera Shin Kanaya Fuminori Gong Jian-Ping Yasuda Kazunori |
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Affiliation: | (1) Department of Sports Medicine and Joint Reconstruction Surgery, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, Japan;(2) Department of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan;(3) Department of Orthopaedic Surgery, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; |
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Abstract: | We have recently discovered that spontaneous hyaline cartilage regeneration can be induced in an osteochondral defect in the
rabbit, when we implant a novel double-network (DN) gel plug at the bottom of the defect. To clarify whether joint immobilization
inhibits the spontaneous hyaline cartilage regeneration, we conducted this study with 20 rabbits. At 4 or 12 weeks after surgery,
the defect in the mobile knees was filled with a sufficient volume of the hyaline cartilage tissue rich in proteoglycan and
type-2 collagen, while no cartilage tissues were observed in the defect in the immobilized knees. Type-2 collagen, Aggrecan,
and SOX9 mRNAs were expressed only in the mobile knees at each period. This study demonstrated that joint immobilization significantly
inhibits the spontaneous hyaline cartilage regeneration induced by the DN gel implantation. This fact suggested that the mechanical
environment is one of the significant factors to induce this phenomenon. |
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