N -琥珀酰壳聚糖的吸湿保湿性评价

以不同黏均分子质量(M0)和不同脱乙酰度(DD)的壳聚糖制备出一系列N-琥珀酰壳聚糖(NSC),研究了NSC的吸湿保湿性、稳定性和与表面活性剂的配伍性,并以透明质酸为对照,测定了NSC在化妆品配方中的保湿性.结果表明在相对湿度81%和32%时,NSC的吸湿保湿性随M0(1.04×106～1.00×105)的降低和DD(44%～100%)的增加而增强;在硅胶中,其吸湿保湿性能随M0的降低和DD的增加而减弱;在不同pH溶液中的特性黏度变化率小于6.5%,能与阴离子和非离子表面活性剂配伍,在化妆品配方中,其保湿性能好于透明质酸.

Hydration and moisturizing property of N-succinyl- chitosan

A series of N-succinyl-KG-*4chitosan with different molecular weights and deacetylation degrees were prepared,and their hydration and retention moisturizing properties as well as the compatibility with surfactants and pH stability of N-(succinyl-)chitosan were studied.The functions as a moisturizing agent in cosmetic cream was compared with hyaluronic acid.The results indicate that the hydration and moisturizing properties of N-succinylKG-*4-chitosan increase with decreasing molecular weight(1.0410~61.0010~5)and increasing deacetylation degree(44 %100 %)under relative humidity 81 % and (32 %).However,in the case of silica gel the negative results are observed.The change of the intrinsic viscosity of N-(succinyl-)chitosan in aqueous solutions with different pH values(5.5,6.0,7.0,8.0)is lower than 6.5 %.N-KG-*4(succinyl-)chitosan is compatible with anionic and nonionic surfactants,the moisturizing effect of N-succinyl-KG-*4chitosan in cosmetic cream is better than that of hyaluronic acid.