| 阿戈美拉汀的合成新工艺 |
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| 引用本文： | 皮威夷,熊丽,罗有福.阿戈美拉汀的合成新工艺[J].四川化工,2013,16(3):1-3. |
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| 作者姓名： | 皮威夷 熊丽 罗有福 |
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| 作者单位： | 四川大学生物治疗国家重点实验室,成都,610041 |
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| 摘 要： | 介绍了以7－甲基四氢萘－1－酮和氰乙酸为原料，合成（7－甲氧基－3，4－二氢－1－萘基）乙腈，再芳构化生成（7－甲氧基－1－萘基）乙腈，再还原乙酰化“一锅”反应得到阿戈美拉汀的全过程。全程反应条件温和，总收率约77％。
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| 关 键 词： | 芳构化 还原乙酰化 阿戈美拉汀 |
The New Technology of Synthesize Agomelatine |
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| Pi Weiyi
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Xiong Li
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Luo Youfu.The New Technology of Synthesize Agomelatine[J].sichuan chemical industry,2013,16(3):1-3. |
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| Authors: | Pi Weiyi Xiong Li Luo Youfu |
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| Affiliation: | (Sichuan university State key laboratory of biotherapy,Chengdu 610041,Sichuan,China) |
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| Abstract: | The text is concerned with a process for the preparation of agomelatine. First the intermediate, namely 2-（7-methoxy-3, 4-dihydronaphthalen-l-yl）acetonitrile, has been prepared by 7-methoxy-3, 4-di- hyctronaphthalen-l（2H）-one and Cyanoacetic acid as raw materials. Further, the intermediate is processed by aromatization to produce 2-（7-methoxynaphthalen-1-yl） acetonitrile. At last, go through reduction and acetylation to get agomelatine. |
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| Keywords: | aromatization reduction and acetylation agomelatine |
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