热粘结复合纤维人造血管支架的制备及其性能

为制备力学性能优异、无细胞毒性和耐穿刺性的小口径人造血管,采用静电纺丝技术结合浸泡脱管法制备了聚己内酯/聚氨酯(PCL/PU)小口径人造血管支架.借助扫描电子显微镜和万能力学拉伸机等对人造血管的形貌结构和力学性能进行测试,同时研究了人造血管支架的孔隙率、细胞毒性和耐穿刺性.结果表明:通过改变接收转辊尺寸,溶去内层聚乙烯...

Preparation and properties of thermal bonded fibrous artificial blood vessels

In order to prepare small-diameter artificial blood vessels with excellent properties, polycaprolactone/polyurethane (PCL/PU) small-diameter artificial blood vessels were prepared by electrospinning technology combined with soaking and tubing-off method, aiming to achieve non-cytotoxicity, puncture resistance, certain porosity and excellent mechanical properties. By means of scanning electron microscope and universal mechanical tensile testing machine, the morphology and mechanical properties of the materials were characterized, and the porosity, cytotoxicity and puncture resistance of artificial blood vessels were studied. The results showed that by changing the size of the receiving roller and then dissolving the inner polyvinyl pyrrolidone, the small diameter artificial blood vessel with the inner diameters of 2, 3, and 5 mm can be obtained. By adjusting the composition ratio and thermal bonding microstructure, the mechanical strength of artificial blood vessels was improved to be 7 times higher compared to the pure PU, with excellent mechanical properties of transverse and longitudinal stretching. The cell viability and porosity of the artificial blood vessel were 94% and 72%, respectively, and the comparison with the commercial expanded polyterafluoroethylene scaffold showed non fluid leakage after puncture.