ROS-mediated TNF-α and MIP-2 gene expression in alveolar macrophages exposed to pine dust |
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| Affiliation: | (1) Institute for Surgical Research, University of Munich, Munich, Germany;(2) Institut f?r Umweltmedizinische Forschung, University of D?sseldorf, D?sseldorf, Germany;(3) Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland |
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| Abstract: | Background Respiratory symptoms, impaired lung function, and asthma have been reported in workers exposed to wood dust in a number of
epidemiological studies. The underlying pathomechanisms, however, are not well understood. Here, we studied the effects of
dust from pine (PD) and heat-treated pine (HPD) on the release of reactive oxygen species (ROS) and inflammatory mediators
in rat alveolar macrophages. |
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