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| 无溶剂条件下DBU催化Knoevenagel缩合反应的研究 | |
| 引用本文： | 王丽敏,胡文姬,皮春燕,应安国. 无溶剂条件下DBU催化Knoevenagel缩合反应的研究[J]. 精细与专用化学品, 2011, 19(7): 16-21 |
| 作者姓名： | 王丽敏 胡文姬 皮春燕 应安国 |
| 作者单位： | 1. 浙江华海药业股份有限公司,浙江临海,317000 2. 浙江医药股份有限公司新昌制药厂,浙江新昌,312500 3. 台州学院医药化工学院,浙江临海,317000 |
| 摘 要： | 建立了一种以有机碱1,8-二氮杂二环（5.4.0）十一稀-7（DBU）为催化剂的无溶剂反应条件的高效、快速和简便的Knoevenagel缩合芳香醛与活泼亚甲基化合物的反应体系。此反应体系能够在室温条件下顺利进行,而且在较短的反应时间内完成反应并得到大于85%的产物收率,且后处理非常简单。最后,讨论了可能的反应机理。 |
| 关 键 词： | Knoevenagel缩合 DBU 芳香醛 无溶剂 |
1,8-Diazabicyclo[5.4.0]-undec-7-ene catalyzed Knoevenagel condensation of aromatic aldehvdes with active methvlene compounds under solvent-free conditions |
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| WANG Li-min,HU Wen-ji,PI Chun-yan,YING An-guo. 1,8-Diazabicyclo[5.4.0]-undec-7-ene catalyzed Knoevenagel condensation of aromatic aldehvdes with active methvlene compounds under solvent-free conditions[J]. Fine and Specialty Chemicals, 2011, 19(7): 16-21 | |
| Authors: | WANG Li-min HU Wen-ji PI Chun-yan YING An-guo |
| Affiliation: | 1.Zhejiang Huahai Pharmaceuticals Co.,Ltd.,Linhai 317000,China; 2.School of pharmaceutical and Chemical Engineering,Taizhou University,Linhai 317000,China; 3.Xinchang Pharmaceuticals Factory,Zhejiang Medicine Co.,Ltd.,Xinchang 312500,China) |
| Abstract: | An efficient,fast and facile reaction system for solvent-free Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by 1,8-diazabicyclo[5.4.0]-undec-7-ene（DBU） was developed. The reaction proceeds smoothly at room temperature and excellent yields（〉85%） was achieved within short time.The work-up procedure is very simple.The possible mechanism was also discussed. |
| Keywords: | Knoevenagel condensation DBU aromatic aldehyde solvent-free |
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