| 天冬甜精中间体的合成优化 |
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| 引用本文： | 崔晓君,陈志荣,鲁波. 天冬甜精中间体的合成优化[J]. 精细化工, 2002, 19(7): 426-428 |
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| 作者姓名： | 崔晓君 陈志荣 鲁波 |
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| 作者单位： | 浙江大学,联合化学反应工程研究所,浙江,杭州,310027 |
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| 摘 要： | 用均匀设计法优化了天冬甜精中间体———N 乙氧硫羰基天冬氨酸的合成反应条件。优化工艺条件为 :反应温度 72℃ ,n(甲基乙基黄原酸酯 )∶n(天冬氨酸 ) =1 5 0∶1 0 0 ,m(天冬氨酸 )∶m(氢氧化钠 ) =0 5 0∶1 0 0 ,m(水 )∶m(天冬氨酸 ) =4 0 0∶1 0 0 ,m(甲醇 )∶m(水 ) =0 15∶1 0 0。N 乙氧硫羰基天冬氨酸的收率为 88 92 %。
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| 关 键 词： | 天冬氨酸 甲基乙基黄原酸酯 均匀设计 |
| 文章编号： | 1003-5214(2002)07-0426-03 |
Optimization for the Synthesis of Aspartame Intermediate |
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| CUI Xiao-jun,CHEN Zhi-rong,LU Bo. Optimization for the Synthesis of Aspartame Intermediate[J]. Fine Chemicals, 2002, 19(7): 426-428 |
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| Authors: | CUI Xiao-jun CHEN Zhi-rong LU Bo |
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| Abstract: | The reaction conditions for synthesizing aspartame intermediate--N-ethoxythiocarbonylaspartic acid were optimized with the uniform design method.The optimized conditions were:reaction temperature 72 ℃,n(methylethylxanthate)∶n(aspartic acid)=1.50∶1.00,m(aspartic acid)∶m(sodium hydroxide)=0.50∶1.00,m(water)∶m(aspartic acid)=4.00∶1.00 and m(methanol)∶m(water)=0.15∶1.00.The yield of N-ethoxythiocarbonylaspartic acid was 88.92%. |
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| Keywords: | aspartic acid methylethylxanthate uniform design |
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