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Effects of N-nitrosopyrrolidine, nitrite and pyrrolidine on tumour development in mice as related to ingestion of cured meat |
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| Authors: | Pearson A M Sleight S D Cornforth D P Akoso B T |
| Affiliation: | a Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824, USA b Department of Pathology, Michigan State University, East Lansing, Michigan 48824, USA |
| Abstract: | The incidence of tumours in mice fed a standard chow diet and given either N-nitrosopyrrolidine (NPyr), nitrite (NO2) or nitrite plus pyrrolidine (NO2 + Pyr) in the drinking water for 12 months at 100mg, 1 g and 1 g plus 100mg/litre, respectively, was compared with that for a control group (C) receiving no additives. Differences between groups in weight gain and feed consumption were not significant. Group 3 (NO2) drank less water (P < 0·05) than those in groups 1 (C) and 2 (NPyr). Water intake of mice in group 4 (NO2 + Pyr) did not differ from that of any of the other three groups. Survival rates were: 94% (C), 80% (NPyr), 92% (NO2) and 83% (NO2 + Pyr); but the differences were not statistically significant. Gross examination upon autopsy revealed that the incidence of all tumours in group 2 (NPyr) was 10- to 20-fold higher than that in any other group. Histological examination confirmed that NPyr induced more (P < 0.05) malignant tumours in liver and lungs with any other treatment; otherwise there were no significant differences. Results indicated that NO2 + Pyr (nitrite plus a secondary amine) did not increase the frequency of carcinogenic tumours in mice. |
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