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Solvent-free synthesis of tri-substituted thiophenes via thio-Claisen rearrangement under microwave irradiation: A convenient route to novel tertiary 2-thienyl amines |
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| Abstract: | A solvent-free, solid-supported, and microwave-assisted thio-Claisen rearrangement of S-propargylated thioamides having an activated α-methylene group has been developed. The methodology could be used successfully for the synthesis of tri-substituted thiophenes and sulfur containing triarylamines. The reaction takes place in short time and in good isolated yield. |
| Keywords: | Thio-Claisen rearrangement Thiophene Microwave irradiation Tertiary amine |