Serum Lipoprotein(a) Levels are Greater in Female than Male Patients with Type-2 Diabetes |
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Authors: | Manouchehr Nakhjavani Afsaneh Morteza Alireza Esteghamati Omid Khalilzadeh Ali Zandieh Reza Safari |
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Affiliation: | (1) Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran |
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Abstract: | Women with diabetes are faced with a higher risk of dyslipidemia and cardiovascular disorders than men with diabetes. We aimed
to study the role of gender and menopausal status in serum Lp(a) levels in patients with type 2 diabetes. We quantified serum
Lp(a) levels in a group of 477 patients with type 2 diabetes (men, premenopausal and postmenopausal women with diabetes),
as well as in 105 controls. We stratified the patients into two groups of low Lp(a) levels (Lp(a) <35 mg/dl) and elevated
Lp(a) levels (Lp(a) >35 mg/dl). Patients with diabetes had higher serum Lp(a) levels than the controls. Serum Lp(a) levels
was significantly higher in women with diabetes than men with diabetes. Lp(a) levels did not differ between male and females
in the control group. Premenopausal and postmenopausal women with diabetes did not differ significantly in serum Lp(a) levels.
The odds ratio of having a serum Lp(a) level higher than 35 was 5.85 in premenopausal women with diabetes, 5.08 in postmenopausal
women with diabetes, 2.41 in men with diabetes and 1.9 in the women in the control group compared to the men in the control
group, after adjustment for age and BMI. This observational study clearly indicated that serum Lp(a) levels were significantly
higher in women and men with diabetes. The increase in women was independent of menopause. The level of serum Lp(a) had no
correlation with lipid parameters in men or women. |
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