Inactivation of the mouse Huntington's disease gene homolog Hdh |
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Authors: | MP Duyao AB Auerbach A Ryan F Persichetti GT Barnes SM McNeil P Ge JP Vonsattel JF Gusella AL Joyner |
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Affiliation: | Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown 02129, USA. |
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Abstract: | Huntington's disease (HD) is a dominant neurodegenerative disorder caused by expansion of a CAG repeat in the gene encoding huntingtin, a protein of unknown function. To distinguish between "loss of function" and "gain of function" models of HD, the murine HD homolog Hdh was inactivated by gene targeting. Mice heterozygous for Hdh inactivation were phenotypically normal, whereas homozygosity resulted in embryonic death. Homozygotes displayed abnormal gastrulation at embryonic day 7.5 and were resorbing by day 8.5. Thus, huntingtin is critical early in embryonic development, before the emergence of the nervous system. That Hdh inactivation does not mimic adult HD neuropathology suggests that the human disease involves a gain of function. |
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