| 聚乳酸微球的制备及应用 |
| |
| 引用本文： | 陆荣,郑雪芹,安晶,董锐.聚乳酸微球的制备及应用[J].工程塑料应用,2009,37(2). |
| |
| 作者姓名： | 陆荣 郑雪芹 安晶 董锐 |
| |
| 作者单位： | 1. 盐城工学院材料工程学院,盐城,224003
2. 盐城工学院实验教学部,盐城,224003 |
| |
| 基金项目： | 江苏省生态环境材料重点实验室重点学科建设开放基金 |
| |
| 摘 要： | 以聚乳酸(PLA)为基体材料,选择聚乙烯醇(PVAL)为乳化剂.采用乳化-溶剂挥发法制备形态较好的PLA微球.在固定可确定因素、保证成球质量的基础上,分别通过调节乳化剂的浓度和其它因素在一定范围内来控制微球的平均粒径.实验结果表明,PLA浓度、乳化剂浓度、搅拌速度、滴加速度4个因素时微球性能影响显著.通过正交实验摸索出制得粒径约为100 μm的PLA微球的最佳工艺方案:搅拌速度为600 r/min,PLA浓度为0.09g/mL,PVAL浓度为0.005 g/mL,滴加速度为1.5 mL/min.这为下一步将此工艺应用于载药微球的研究奠定了基础.
|
| 关 键 词： | 聚乳酸 微球 制备 应用 正交设计 |
PREPARATION AND APPLICATION OF PLA MICROPHERES |
| |
| Lu Rong,Zheng Xueqin,An Jing,Dong Rui.PREPARATION AND APPLICATION OF PLA MICROPHERES[J].Engineering Plastics Application,2009,37(2). |
| |
| Authors: | Lu Rong Zheng Xueqin An Jing Dong Rui |
| |
| Affiliation: | School of Materials Engineering;Yancheng Institute of Technology;Yancheng 224003;China;Department of Experiment Teaching;China |
| |
| Abstract: | Polylactic acid(PLA) microspheres were prepared through emulsion/solvent evaporation method by choosing PLA as foundation material and polyvinyl alcohol as emulsifier.On the basis of ensuring the quality of produced particles,the concentration of emulsifier and other factors were adjusted in a certain range to control the average particle sizes of microspheres after the confirmable factors were fixed.Single factor experiment results showed that there were four factors significantly affecting the performance... |
| |
| Keywords: | polylactic acid microspheres preparation application orthogonal-designed method |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
