Surface Modification of Biomedical and Dental Implants and the Processes of Inflammation,Wound Healing and Bone Formation |
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Authors: | Clark M Stanford |
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Affiliation: | Dows Institute for Dental Research, College of Dentistry, University of Iowa, IA 52242, USA; E-Mail: ; Tel.: +1-319-335-7381; Fax: +1-319-335-8895 |
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Abstract: | Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new osteoblast differentiation on the implant surface. The complex role of implant surface topography and impact on healing response plays a role in biological criteria that can guide the design and development of future tissue-implant surface interfaces. |
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Keywords: | implant surfaces wound healing macrophage |
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