| 脑缺血/再灌注对大鼠脑内花生四烯酸乙醇胺浓度的影响及其机理初步研究 |
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| 引用本文： | 李晶,董志,乐乐乐.脑缺血/再灌注对大鼠脑内花生四烯酸乙醇胺浓度的影响及其机理初步研究[J].四川激光,2010(3):93-93,96. |
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| 作者姓名： | 李晶 董志 乐乐乐 |
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| 作者单位： | 重庆医科大学药学院,重庆400016 |
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| 基金项目： | 国家自然科学基金项目（30572074/c1612） |
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| 摘 要： | 目的：脑缺血再灌注对脑组织中大麻内源性配体花生四烯酸乙醇胺（AEA）含量变化的影响。方法：用高效液相色谱法分别测定脑缺血、再灌注与对照组脑组织中AEA的浓度含量。结果：脑缺血及再灌注大鼠脑内AEA明显改变,浓度高于对照组,脑内AEA浓度在3小时缺血后显著增加,差异具有统计学意义。结论：脑缺血/再灌注导致脑组织中AEA浓度明显升高,AEA可能在脑缺血早期发挥了保护作用。
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| 关 键 词： | 局部脑缺血 缺血再灌注 AEA 神经保护作用 高效液相色谱 |
An investigation about focal cerebral ischemia and ischaemia-reperfusion effects on endocannabinoid changes and role of anandamide in cerebral ischemia |
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| LI Jing,DONG Zhi,LE Le-le.An investigation about focal cerebral ischemia and ischaemia-reperfusion effects on endocannabinoid changes and role of anandamide in cerebral ischemia[J].Laser Journal,2010(3):93-93,96. |
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| Authors: | LI Jing DONG Zhi LE Le-le |
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| Affiliation: | (Pharmacy College,Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | Obejective：To investigate the change of Anandamide content during transient,focal cerebral ischemia.Methods：In this study,transient middle cerebral artery occlusion（MCAo） was used to produce ischemia/reperfusion injury.Brain tissues content of N-arachidonoylethanolamine（AEA） were determined by HPLC during MCAo and Ischemia/reperfusion.Results：Whole brain AEA content was significantly increased after 3h MCAo compared with sham-operated brain.Conclusion：The increase in AEA is protective during transient,focal cerebral ischemia. |
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| Keywords: | focal cerebral ischemia IR anandemide neurological protective HPLC |
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