急进高原个体胆汁返流与急性胃肠粘膜损伤的关系探讨

目的：对急进高原个体胆汁返流与急性胃肠粘膜损伤的关系进行探讨。方法：对20例由平原急进高原个体进入高原前、进入高原第3天和第7天进行胃镜检查,对其胆汁返流、胃黏膜损伤及其消化系统的症状发生情况进行调查。结果：20例急进高原个体进入高原后胆汁返流及胃粘膜损伤与进入高原前比较,除进入高原第7天胆汁返流无显著差异外,其余均有显著差异（分别为P〈0.01和P〈0.05）,其中胆汁返流进入高原前、进入高原第3天及第7天分别为0例（0%）1、0例（50%）、5例（25%）;粘膜损伤分别为2例（10%）1、7例（85%）、10例（50%）;其中13例有不同程度的消化系统症状（占65%）。结论：高原急性缺氧可引发急进高原个体胆汁返流的高发生率,并因此而导致急性胃肠粘膜损伤。

Discussion of relationship between acute damage of gastric and intestinal mucosal and bile refiuxing under acute hypoxia exposed in plateau

Objective：Discuss the relationship between acute damage of gastric and intestinal mucosal and bile refluxing under acute hypoxia exposed in plateau.Methods：Take examination of gastroscopy for 20 people who entered into plateau rapidly in I day before they entered into plateau and 3,7 days after they entered into plateau separately,investigate the happen of bile refluxing,injury of gastric mucosal and digesting symptoms after people entered into plateau.Result： Except no dramatically difference was found to the happening of bile refluxing in 7 days group,there were significant diversity of bile refluxing and injury of gastric mucosal after acute hypoxia exposed in plateau（P〈0.05,P〈0.01）.The cases who got bile refluxing are 0（0%）,10（50%）,5（25%） in I day before they entered into plateau and 3,7 days after they entered into plateau separately;and people who got injury of gastric mucosal are 2（10%）,17（85%）,10（50%） at the same time.13 persons（65%） had different degree of digesting symptoms after they entered into plateau all together.Conclusion：Acute expose of hypoxia in plateau can cause significant increase of bile refluxing,then result in acute damage of gastric and intestinal mucosal.