Structure based design: novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors |
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Authors: | AK Ghosh K Krishnan DE Walters W Cho H Cho Y Koo J Trevino L Holland J Buthod |
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Affiliation: | Department of Chemistry, University of Illinois at Chicago 60607, USA. |
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Abstract: | A series of novel spirocyclic ethers were designed to function as nonpeptidal P2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors. |
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