Design of the polyacrylonitrile-reduced graphene oxide nanocomposite-based non-enzymatic electrochemical biosensor for glucose detection

With the advantages of developed electronic devices, various biosensor applications have become attractive issues with excellent electrochemical performances against biomarkers and molecules in biomedical applications. In this study, novel polyacrylonitrile (PAN)-reduced graphene oxide (rGO) nanocomposite-based non-enzymatic electrochemical biosensors were prepared to investigate the detection performance of the glucose. The PAN-rGO nanocomposite-based biosensor detected glucose with a high sensitivity and stability due to enhanced redox mechanism arising from rGO additive. PAN-rGO nanocomposite-based biosensor detected glucose in (0.75–12) mM with a high sensitivity of 49 µAmM^?1 cm^?2 (2.5 times higher than PAN-based sensor). Concentration–response graphs correlating the non-enzymatic electrochemical signal to glucose concentration revealed a low limit of detection (LOD) of 0.6 mM within 1-min voltammetric cycle. The selectivity results confirmed a significant preferential response of the proposed PAN-rGO nanocomposite-based biosensor for glucose against possible interfering compounds. The proposed PAN-rGO nanocomposite-based biosensor has a great potential to be used as a nanostructured platform for detection of glucose in phosphate-buffered saline (pH 7.4) solution with high sensitivity, selectivity, stability, reproducibility, and fast response properties.