| 3-醛基吲哚-5-甲酸乙酯的合成 |
| |
| 引用本文： | 葛裕华,吴亚明,薛忠俊. 3-醛基吲哚-5-甲酸乙酯的合成[J]. 化学试剂, 2006, 28(2): 123-123,125 |
| |
| 作者姓名： | 葛裕华 吴亚明 薛忠俊 |
| |
| 作者单位： | 东南大学,化学化工系,江苏,南京,210096;东南大学,化学化工系,江苏,南京,210096;东南大学,化学化工系,江苏,南京,210096 |
| |
| 摘 要： | 报道了以3-甲基-4-硝基苯甲酸为原料的标题化合物的合成方法,总收率达63%。其结构经1HNMRI、R和MS得到确证。
|
| 关 键 词： | 3-醛基吲哚-5-甲酸乙酯 吲哚-5-甲酸乙酯 合成 |
| 文章编号： | 0258-3283（2006）02-0123-01 |
| 收稿时间： | 2005-03-30 |
| 修稿时间： | 2005-03-30 |
Synthesis of ethyl 3-formylindole-5-carboxylate |
| |
| GE Yu-hua,WU Ya-ming,XUE Zhong-jun. Synthesis of ethyl 3-formylindole-5-carboxylate[J]. Chemical Reagents, 2006, 28(2): 123-123,125 |
| |
| Authors: | GE Yu-hua WU Ya-ming XUE Zhong-jun |
| |
| Affiliation: | Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096,China |
| |
| Abstract: | The synthesis method of a new compound ethyl 3-formylindole-5-carboxylate(1)has been reported.The intermediate ethyl indole-5-carboxylate was obtained from 3-methyl-4-nitrobenzoic acid as raw material by esterification with EtOH,condensation with DMFDEA and piperidine,reduction with Fe/HAc.Then it was reacted with POCl_3/DMF through Vilsmeier-Hacck reaction,the target product 1 was synthesized with a total yield of 63%.The structure of 1 was confirmed by(()~1HNMR),IR and MS. |
| |
| Keywords: | ethyl 3-formylindole-5-carboxylate ethyl indole-5-carboxylate synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
