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Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering |
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| Authors: | Paola Fabbri Federica Bondioli Massimo Messori Cristina Bartoli Dinuccio Dinucci and Federica Chiellini |
| Affiliation: | (1) Department of Materials and Environmental Engineering, University of Modena and Reggio Emilia, Via Vignolese 905/a, 41100 Modena, Italy;(2) Department of Chemistry and Industrial Chemistry, University of Pisa, Via Vecchia Livornese 1291, S. Piero a Grado, 56122 Pisa, Italy;(3) Consorzio Interuniversitario Nazionale di Sienza e Tecnologia dei Materiali, INSTM, Via Giusti 9, 50121 Florence, Italy;(4) BIOlab–Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications, INSTM Consortium Reference Center, Pisa, Italy |
| Abstract: | Polycaprolactone/hydroxyapatite (PCL/HA) composites were prepared by in situ generation of HA in the polymer solution starting from the precursors calcium nitrate tetrahydrate and ammonium dihydrogen phosphate via sol–gel process. Highly interconnected porosity was achieved by means of the salt-leaching technique using a mixture of sodium chloride and sodium bicarbonate as porogens. Structure and morphology of the PCL/HA composites were investigated by scanning electron microscopy, and mechanical properties were determined by means of tensile and compression tests. The possibility to employ the developed composites as scaffolds for bone tissue regeneration was assessed by cytotoxicity test of the PCL/HA composites extracts and cell adhesion and proliferation in vitro studies. |
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