Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats |
| |
Authors: | Zengyong Qiao Jiangwei Ma Huajin Liu |
| |
Affiliation: | Department of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Shanghai, 201400 China; E-Mails: liuhjdrfx@sina.cn (L.H.); E-Mail: majwdrfx@sina.cn (M.J.). |
| |
Abstract: | We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury. Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with 0.2%, 0.4% or 0.6% Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to global ischemia for 30 min followed by reperfusion for 2 h. The hearts were compared for indices of oxidative stress and immunity activities. Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na(+)-K(+)-ATPase, Ca(2+)-Mg(2+)-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities. The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats. |
| |
Keywords: | ischemic reperfusion injury antioxidant immunity Ligusticum wallichii extract |
本文献已被 PubMed 等数据库收录! |
|