| 重组家蚕抗菌肽CM4对癌细胞骨架及核骨架破坏作用的观察 |
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| 引用本文： | 赵东红,张双全,戴祝英,濮祖茂. 重组家蚕抗菌肽CM4对癌细胞骨架及核骨架破坏作用的观察[J]. 高技术通讯, 2000, 10(1): 23-27 |
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| 作者姓名： | 赵东红 张双全 戴祝英 濮祖茂 |
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| 作者单位： | 1. 南京师范大学生命科学学院,南京,210097
2. 中国药科大学电镜室,南京,210009 |
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| 基金项目： | 国家自然科学基金，39570111， |
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| 摘 要： | 报道了重组家蚕抗菌肽ＣＭ４对离体Ｕ９３７，Ｈｅｌａ癌细胞骨架及核骨架损伤作用的扫描电镜观察。随着时间的延长，经重组家蚕抗菌肽ＣＭ４作用后的癌细胞骨架散乱，断裂，萎缩成团状；癌细胞呆断裂，部分凝聚成团，结构不完整。重组家蚕抗菌肽ＣＭ４与正常人白细胞作用后细胞骨架及核骨架未见损伤现象。
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| 关 键 词： | 抗菌肽 癌细胞 抗癌试验 核骨架 重组家蚕抗菌肽 |
Studies on the Effect of Recombined Cecropin CM4 Breaking Cytoskeleton and Nuclear Matrix-intermediate of Cancer Cells |
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| Zhao Donghong,Zhang Shuangquan,Dai Zhuying,Pu Zumao. Studies on the Effect of Recombined Cecropin CM4 Breaking Cytoskeleton and Nuclear Matrix-intermediate of Cancer Cells[J]. High Technology Letters, 2000, 10(1): 23-27 |
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| Authors: | Zhao Donghong Zhang Shuangquan Dai Zhuying Pu Zumao |
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| Abstract: | The effect of recombined cecropin CM 4 component on the cytoskeleton and nuclear matrix (NM) intermediate filament (IF) system of U937 & Hela cancer cells is reported. The results show that the recombined cecropin CM 4 can cause the cancer cell cytoskeleton disordered, folded and damaged, and the NM IF system is broken and injured. The recombined cecropin CM 4 component do not injure the cytoskeleton and nuclear matrix (NM) intermediate filament (IF) system of the normal human leucocytes. |
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| Keywords: | Cecropin Cancer cell Cytokeleton Nuclear matrix intermediate |
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