| 石榴皮水提物对中华大蟾蜍心电活动的影响 |
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| 引用本文： | 祝建平,刘瑜,张立盈,崔希云,艾洪滨. 石榴皮水提物对中华大蟾蜍心电活动的影响[J]. 食品与药品, 2009, 0(9) |
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| 作者姓名： | 祝建平 刘瑜 张立盈 崔希云 艾洪滨 |
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| 作者单位： | 山东师范大学生命科学学院; |
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| 基金项目： | 山东省教育厅科技计划项目,J08LE63 |
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| 摘 要： | 目的观察石榴皮水提物对中华大蟾蜍心电活动的影响。方法腹腔分别注射1,10,100mg/mL3种不同浓度的石榴皮水提物溶液1mL,记录麻醉状态下,中华大蟾蜍给药前后II导联心电图波形的变化,观察其心率,P波、R波、S波、P-R段、S-T段、QRS波群持续时间及波幅变化。结果与给药前相比,10,100mg/mL2种浓度的石榴皮水提物均使动物心率显著变慢;随着给药时间延长心率变慢更趋明显,一直持续到给药后30min;而1mg/mL组的心率随实验时间的延长也变慢,但无显著差异。3组动物P波、R波、S波、P-R段及S-T段的持续时间和波幅变化与给药前相比均无显著差异;10mg/mL组的QRS波群时程在给药15～30min期间显著延长。结论10,100mg/mL石榴皮水提物对麻醉蟾蜍的心率和心电活动均有抑制作用;石榴皮水提物对麻醉蟾蜍心电活动的调节作用主要表现为影响心室的去极化过程,对心房去极化及复极化过程的影响均不显著。
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| 关 键 词： | 石榴皮水提物 蟾蜍 心电图 心率 |
Effect of Water Extraction from Pomegranate Peel on Cardiac Electrical Activity of Bufo Bufo Gargarizans in Vivo |
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| ZHU Jian-ping,LIU Yu,ZHANG Li-ying,CUI Xi-yun ,AI Hong-bin. Effect of Water Extraction from Pomegranate Peel on Cardiac Electrical Activity of Bufo Bufo Gargarizans in Vivo[J]. Food and Drug, 2009, 0(9) |
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| Authors: | ZHU Jian-ping LIU Yu ZHANG Li-ying CUI Xi-yun AI Hong-bin |
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| Affiliation: | College of Life Science;Shandong Normal University;Jinan 250014;China |
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| Abstract: | Objective To determinate the effect of water extraction of pomegranate peel on the cardiac electrical activity of Bufo Bufo Gargarizans in vivo. Methods The animals were injected abdominally with different concentrations of 1 mL water extraction from pomegranate peel (1 mg/mL, 10 mg/mL, 100 mg/mL). The II-lead electrocardiography(ECG)was recorded before and after injecting drugs. The changes of heart rate, durations and amplitudes of P, R, S, P-R segment, S-T segment and QRS complex were observed. Results I... |
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| Keywords: | water extraction of pomegranate peel toad electrocardiography heart rate |
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