| N-甲基-2-[4-(4-氯苯氧基)苯氧基]乙酰胺的合成 |
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| 引用本文： | 姜荫,王红,高永红.N-甲基-2-[4-(4-氯苯氧基)苯氧基]乙酰胺的合成[J].化学世界,2009,50(6). |
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| 作者姓名： | 姜荫 王红 高永红 |
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| 作者单位： | 1. 上海应用技术学院,现代教育中心,上海,200235
2. 上海应用技术学院,化学工程系,上海,200235 |
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| 基金项目： | 上海市教育委员会发展基金 |
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| 摘 要： | 在无水碳酸钾存在下,N,N-二甲基甲酰胺为溶剂,由2-氯乙酰甲胺和4-苯氧基苯酚反应,制备了N-甲基-2-(4-苯氧基苯氧基)乙酰胺。而后,以乙腈和四氯化碳为混合溶剂,磺酰氯和N-甲基-2-(4-苯氧基苯氧基)乙酰胺反应,得到目的产物。着重考察了反应温度、反应时间、物料摩尔比对目的产物收率的影响。从而确定了产物的合成工艺条件为:反应温度40℃,反应时间5 h,nN-甲基-2-(4-苯氧基苯氧基)乙酰胺]∶n(磺酰氯)=1∶1.4;在此条件下,产物的收率达80%以上。经IR、MS1、H NMR确定为N-甲基-2-4-(4-氯苯氧基)苯氧基]乙酰胺。
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| 关 键 词： | 2-氯乙酰甲胺 N-甲基-2-(4-苯氧基苯氧基)乙酰胺 N-甲基-2-[4-(4-氯苯氧基)苯氧基]乙酰胺 氯化 |
N-Methyl-2-[4-(4-chlorophenoxy)phenoxy] Acetamide |
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| JIANG Yin,WANG Hong,GAO Yong-hong.N-Methyl-2-[4-(4-chlorophenoxy)phenoxy] Acetamide[J].Chemical World,2009,50(6). |
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| Authors: | JIANG Yin WANG Hong GAO Yong-hong |
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| Affiliation: | Department of Chemical Engineering;Shanghai Institute of Technology;Shanghai 200235;China |
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| Abstract: | N-Methyl-2-(4-phenoxyphenoxy) acetamide was synthesized from 4-phenoxyphenol and 2-chloroacetyl methylamine with DMF as solvent and potassium carbonate as catalyst.Then it was reacted with sulfuryl chloride using acetonitrile and carbon tetrachloride as organic solvent to get N-methyl-24-(4-chlorophenoxy)phenoxy] acetamide.The effect of reaction temperature, reaction time,mole ratio of N-methyl-2-(4-phenoxyphenoxy) acetamide to sulfuryl chloride on yield of N-methyl-2-4-(4-chlorophenoxy)phenoxy] acetamide... |
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| Keywords: | 2-chloroacetyl methylamine N-methyl-2-(4-phenoxyphenoxy) acetamide N-methyl-2-[4-(4-chlorophenoxy)phenoxy] acetamide chlorination |
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