| 脂肪酶催化的丁基苯酞的酰化反应的研究 |
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| 引用本文： | 何腊平,孙颎,徐岩,孙志浩.脂肪酶催化的丁基苯酞的酰化反应的研究[J].食品与发酵工业,2008,34(4):64-67. |
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| 作者姓名： | 何腊平 孙颎 徐岩 孙志浩 |
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| 作者单位： | 1. 江南大学生物工程学院教育部工业生物技术重点实验室,江苏无锡,214122
2. 江南大学生物工程学院教育部工业生物技术重点实验室,江苏无锡,214122;中国食品发酵工业研究院,北京,100027 |
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| 基金项目： | 教育部长江学者和创新团队发展计划 |
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| 摘 要： | 在正己烷溶剂中脂肪酶Novozym 435可催化丁基苯酞的酸解和转酯化反应。对于酸解反应,可以用饱和盐溶液预平衡法或者直接加水合盐法来控制反应体系的水活度,最适水活度为0.62,相应的丁基苯酞的转化率为15.9%。对于转酯化反应,适宜的反应体系是加水合盐到反应体统中,最适水活度亦为0.62,相应的丁基苯酞的转化率为49.4%。而且Novozym435对外消旋的丁基苯酞具有拆分效果。
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| 关 键 词： | 丁基苯酞 Novozym 435 酸解 转酯化 水活度 |
| 修稿时间： | 2007年7月9日 |
The Study on the Acylation of 3-n-butylphthalide Catalyzed by Lipase |
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| He Laping,Sun Jiong,Xu Yan,Sun Zhihao.The Study on the Acylation of 3-n-butylphthalide Catalyzed by Lipase[J].Food and Fermentation Industries,2008,34(4):64-67. |
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| Authors: | He Laping Sun Jiong Xu Yan Sun Zhihao |
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| Abstract: | Lipase Novozym 435 could catalyze acidolysis and transesterification of 3-n-butylphthalide in hexane.The ways to control water activity by preequilibration with saturated salt solution and direct addition of salthydrate were all available for the acidolysis of 3-n-butylphthalide.The optimum water activity was 0.62 and corresponding conversion of 3-n-butylphthalide was 15.9% for the acidolysis.The suitable reaction system was direct addition of salthydrate to the reaction system of transesterification of 3-n-butylphthalide. The optimum aw was also 0.62 and corresponding conversion of 3-n-butylphthalide was 49.4 % for the trans- esterification.Furthermore,resolution of racemic 3-n-butylphthalide could be catalyzed by Novozym 435. |
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| Keywords: | 3-n-butylphthalide Novozym 435 acidolysis transesterification water activity |
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