Promyelocytic blast crisis of chronic myelogenous leukaemia with translocations (9;22) and (15;17) |
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| Authors: | MP Scolnik MF Palacios SH Acevedo MV Castuma IB Larripa A Palumbo EB Moiraghi AM Sasot AB Huberman |
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| Affiliation: | First Department of Surgery, Kyoto Prefectural University of Medicine, Japan. |
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| Abstract: | The murine monoclonal antibody A7 (MAb A7) is reactive against most human gastric cancer cell lines. Using a nude mouse peritoneal dissemination model of human gastric cancer, we investigated targeted chemotherapy using a conjugate of neocarzinostatin (NCS) with MAb A7 (A7-NCS). After demonstrating cytotoxicity of the complex against the human gastric cancer cell line MKN45 in vitro, we intraperitoneally injected A7-NCS, NCS or saline into nude mice bearing peritoneally disseminated human gastric cancer. A7-NCS inhibited peritoneal dissemination significantly more effectively than NCS. MAb A7 may prove to be an effective carrier for antineoplastic drugs in patients with peritoneal dissemination of gastric cancer. |
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