| 4-硝基苄醇的合成 |
| |
| 引用本文： | 梁大伟,王悦秋,王艳艳.4-硝基苄醇的合成[J].化学与生物工程,2014(12):51-53. |
| |
| 作者姓名： | 梁大伟 王悦秋 王艳艳 |
| |
| 作者单位： | 1. 雅安职业技术学院药学检验系,四川 雅安,625000
2. 江苏联合职业技术学院 连云港中医药分院中医药系,江苏 连云港,222007 |
| |
| 摘 要： | 以4-硝基甲苯为原料,经过芐位溴代生成4-硝基芐基溴,然后与无水乙酸钠在相转移催化剂作用下生成乙酸对硝基芐酯,最后在15%NaOH溶液中水解合成4-硝基苄醇。考察了不同的溴代试剂和相转移催化剂对反应收率的影响。结果表明,当采用Br2（1.1eq）-H2O2（30%,1.1eq）-AIBN（0.05eq）为溴代试剂、四丁基溴化铵（0.05eq）为相转移催化剂时,总收率达44.6%。该合成路线操作容易,后处理简便,且反应溶剂及重结晶溶剂都可以回收重复利用,具有工业化应用前景。
|
| 关 键 词： | 4-硝基甲苯 4-硝基苄醇 溴代 相转移催化剂 合成 |
Synthesis of 4-Nitrobenzyl Alcohol |
| |
| LIANG Da-wei,WANG Yue-qiu,WANG Yan-yan.Synthesis of 4-Nitrobenzyl Alcohol[J].Chemistry & Bioengineering,2014(12):51-53. |
| |
| Authors: | LIANG Da-wei WANG Yue-qiu WANG Yan-yan |
| |
| Affiliation: | LIANG Da-wei;WANG Yue-qiu;WANG Yan-yan;Department of Pharmacy Control,Ya′an Vacational College;Department of Traditional Chinese Medicine,Lianyungang TCM Branch of Jiangsu Union Technical Institute; |
| |
| Abstract: | Using 4-nitrotoluene as raw material,4-nitrobenzyl bromide was formed by benzylic bromination,then by esterification with sodium acetate under the catalysis of PTC to formp-nitrobenzyl acetate,after hydrolysis in 15%NaOH solution,4-nitrobenzyl alcohol was synthesized.The effects of bromination agents and PTC on the yield of the reaction were investigated.The results showed that,when using Br2（1.1eq）-H2O2（30%,1.1eq）-AIBN（0.05eq）as bromination agent,tetrabutylammonium bromide as PTC,the total yield of 4-nitrobenzyl alcohol was 44.6%.This synthetic route is simple,easy in post-operation,all the solvents in reaction and recrystallization can be reused,and had a promising industrialized future. |
| |
| Keywords: | 4-nitrotoluene 4-nitrobenzyl alcohol bromination PTC synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
