阿莫西林、甲硝唑和胶体次枸橼酸铋三种药物联用对大鼠胃溃疡模型的影响

目的: 观察阿莫西林、甲硝唑和胶体次枸橼酸 铋联合使用对3 种大鼠胃溃疡模型的影响, 为临床 合理选用药物治疗消化道溃疡提供参考。方法: 用 大鼠做成水浸应激性胃溃疡、幽门结扎型胃溃疡及 乙酸烧灼型胃溃疡3 种模型, 试验组给予阿莫西林 (225 mg·kg^-1) 、甲硝唑(112 mg·kg^-1) 和胶体次枸橼 酸铋(56 mg·kg^-1) 混合物;阳性对照组给予西咪替 丁(112 mg·kg^-1); 阴性对照组给予2 %羧甲基纤维 素钠(CMC-Na) 。结果: 试验组呈剂量依赖性保护大 鼠水浸应激性胃溃疡形成, 有效剂量为 112 mg·kg^-1;呈剂量依赖性保护大鼠幽门结扎型溃 疡形成, 有效剂量为56 mg·kg^-1;呈剂量依赖性促进 大鼠乙酸烧灼溃疡的愈合, 有效剂量为 112 mg·kg^-1。结论: 试验组呈剂量依赖性对大鼠水 浸应激性胃溃疡显示保护作用;呈剂量依赖性减少 大鼠幽门结扎型胃溃疡的程度;呈剂量依赖性促进 乙酸烧灼溃疡的愈合, 但作用均弱于西咪替丁。

Effects of combination of amoxicillin,metronidazole and colloidal bismuth subcitrate on gastric ulcer in rats

AIM: To study the effects of combination usage of amoxicillin (A), metronidazole (M) and colloidal bismuth subcitrate (B) on gastric ulcer in rats and to provide the clinical reasonable medication reference on peptic ulcer.METHODS: 40 rats were divided into 5 groups (n =8 in each): the test groups with the administration of mixture of A, M and B 225, 112 and 56 mg·kg^-1, respectively; the positive control group with the administration of cimetidine 112 mg·kg^-1and the negative control group with the administration of 2 % CMCNa. Two-thirds of rats in each group were given drugs before being made the gastric ulcer animal models induced by stress and pyloric ligation, and the other one-third of rats in each group were given drugs after being made the gastric ulcer models induced by acetic acid injury.RESULTS: The mixture prevented the formation of gastric ulcer induced by stress and pyloric ligation, and healed the gastric ulcer induced by acetic acid injury at the dosage of 112, 56 and 56 mg·kg^-1, respectively.CONCLUSION: The mixture can dose-dependently protect the gastric ulcer induced by stress, reduce the degree of gastric ulcer induced by pylorus ligation, and advance the healing rate of gastric ulcer induced by acetic acid injury, but its effect is lower than that of cimetidine.