| 靶向内皮细胞α7受体的新化合物对鸡胚绒毛尿囊膜血管生成的影响 |
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| 引用本文： | 刘静霞,龙超良,包存刚,汪海. 靶向内皮细胞α7受体的新化合物对鸡胚绒毛尿囊膜血管生成的影响[J]. 金属学报, 2004, 9(7): 747-750 |
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| 作者姓名： | 刘静霞 龙超良 包存刚 汪海 |
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| 作者单位： | 中国人民解放军304 医院, 北京100037;1.军事医学科学院毒物药物研究所, 北京100850;2.赛德维康医药研究院, 北京100850 |
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| 基金项目： | 国家重点基础研究发展规划项目(№G1998051112) |
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| 摘 要： | 目的: 研究靶向内皮细胞α7 受体的新化合物对鸡胚绒毛尿囊膜(CAM)血管新生的影响。方法: 应用鸡胚绒毛尿囊膜模型,通过计数血管的分支点数,观察16种靶向内皮细胞α7受体的新化合物对于在体血管新生的影响。结果与结论: 化合物13、14在1~100μmol·L-1浓度范围内,既没有促进血管新生的作用,也没有抑制血管新生的作用,与生理盐水组相比无显著差异,而在浓度为1000μmol·L-1时,对CAM的血管新生有促进作用。化合物5在浓度为100和1000μmol·L-1有抑制血管新生的作用,而在浓度为1和10μmol·L-1时,则对血管新生没有影响。
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| 关 键 词： | 新化合物,内皮细胞,α7 nAChR ,鸡胚绒毛尿囊膜,血管新生, |
| 收稿时间： | 2004-04-22 |
| 修稿时间： | 2004-05-13 |
Effects of new compounds on angiogenesis in chick chorioallantoic membranes targeting on α7 receptor of endothelial cells |
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| LIU Jing-Xia,LONG Chao-Liang,BAO Cun-Gang,WANG Hai. Effects of new compounds on angiogenesis in chick chorioallantoic membranes targeting on α7 receptor of endothelial cells[J]. Acta Metallurgica Sinica, 2004, 9(7): 747-750 |
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| Authors: | LIU Jing-Xia LONG Chao-Liang BAO Cun-Gang WANG Hai |
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| Affiliation: | The 304th Hospital of PLA, Beijing 100037, China;1.Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;2.Thadweik Institute of Medicine, Beijing 100850, China |
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| Abstract: | AIM: To investigate the effects of new compounds on angiogenesis of chick chorioallantoic membranes (CAM) targeting on α7 receptor in endothelial cells.METHODS: The blood vessels of CAM were calculated to determine the antiangiogenic effects of 16 new compounds targeting on α7 receptor in endothelium.RESULTS AND CONCULSION: Compared with saline control, compound 13 and 14 between the concentrations 1 and 100 μmol·L-1 had no effects on angiogenesis.They neither stimulated nor inhibited the angiogenesis.But at the concentration of 1 000 μmol·L-1, both of them could stimulate angiogenesis significantly.Under the same experimental conditions, compound 5 at the concentrations of 100 and 1 000 μmol·L-1 could inhibit angiogenesis.But it had no effect on angiogenesis at the concentrations of 1 and 10 μmol·L-1. |
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| Keywords: | new compound,endothelial cells,α7nAChR ,chick chorioallantoic membranes,angiogenesis, |
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