草分枝杆菌联合顺铂治疗恶性胸腔积液的临床评价

目的: 观察草分枝杆菌胸腔内注射治疗恶性胸腔积液的近期疗效、毒副反应及其对患者T 淋巴细胞亚群水平的影响。方法: 将62 例恶性胸腔积液患者随机分成试验组和对照组, 先尽量排完胸腔积液, 试验组向胸腔内注射生理盐水20 ml +草分枝杆菌8.6 μg +顺铂40 mg;对照组向胸腔内注射生理盐水20 ml +顺铂40 mg, 每周1 次, 连续1 ~ 3 次,1 mon 后观察疗效及治疗前后T 淋巴细胞亚群水平变化。结果: 试验组总有效率为87.5 %, 高于对照组(P<0.01), 毒副反应少而轻微。治疗后CD⁺₃ 、CD⁺₄ 及CD⁺₄ CD⁺₈ 明显升高(P<0.01 或0.05),CD⁺₈ 显著降低(P<0.01) 。结论: 草分枝杆菌联合顺铂治疗恶性胸腔积液疗效肯定, 副反应少, 且能明显改善患者T 淋巴细胞亚群抑制状态。

Clinical evaluation of mycobacterium phlei combined with cisplatin in treatment of patients with malignant pleural effusion

AIM: To evaluate the efficacy, safety and effects on changes of T-lymphocyte subsets of mycobacterium phlei and cisplatin in treatment of patients with malignant pleural effusion (MPE).METHODS: 62 patients of MPE were randomly assigned to two groups.The test group was treated once aweek lasting for 1-3 weeks with NS 20 ml +mycobacterium phlei 8.6 μg +cisplatin 40 mg, while the control one with NS 20 ml +cisplatin 40mg only.The efficacy and changes of T-lymphocyte subsets before and after therapy were analyzed separately.RESULTS: The overall response rate in the test group was 87.5 %, which meant significantly higher than that in the control group (P<0.01), and the side effects were mild.After the treatment, the levels of CD⁺₃ and CD⁺₄ cells and the ratio of CD⁺₄ CD⁺₈ increased greatly (P<0.05 or 0.01), while the level of CD⁺₈ dropped sharply(P<0.01).CONCLUSION: The therapy of mycobacterium phlei combined with cisplatin is effective in controlling the MPE with low side-effect, and can greatly improve the inhibition of T-lymphocyte subsets in patients with MPE.