| 氯胺酮对腹腔感染脓毒症小鼠生存率的影响 |
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| 引用本文： | 刘芬,陈金和,李声华,赵文辉,艾永循.氯胺酮对腹腔感染脓毒症小鼠生存率的影响[J].金属学报,2004,9(8):942-944. |
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| 作者姓名： | 刘芬 陈金和 李声华 赵文辉 艾永循 |
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| 作者单位： | 江汉大学附属医院麻醉科, 武汉430015, 湖北 |
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| 摘 要： | 目的: 探讨早期使用氯胺酮是否延迟盲肠结扎穿孔(CLP)所致脓毒症小鼠的死亡时间。方法: 60只CLP小鼠,分别于术后1、6 h 腹腔注射氯胺酮0、3、6、12 mg·100 g-1,观察小鼠死亡情况并比较累计生存率。结果: 氯胺酮延长CLP小鼠死亡时间(P<0.05);氯胺酮6 mg·100 g-1组小鼠生存时间明显长于3 mg·100 g-1组和12 mg·100 g-1组(P<0.05)。结论: 氯胺酮延迟CLP小鼠死亡时间,并呈现剂量依赖性。
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| 关 键 词： | 氯胺酮 盲肠结扎穿孔 脓毒症 小鼠 生存率 |
| 收稿时间： | 2004-04-15 |
| 修稿时间： | 2004-06-26 |
Effects of ketamine on cumulative survival in septic mice induced by cecal ligation and puncture |
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| LIU Fen,CHEN Jin-He,LI Sheng-Hua,ZHAO Wen-Hui,AI Yong-Xun.Effects of ketamine on cumulative survival in septic mice induced by cecal ligation and puncture[J].Acta Metallurgica Sinica,2004,9(8):942-944. |
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| Authors: | LIU Fen CHEN Jin-He LI Sheng-Hua ZHAO Wen-Hui AI Yong-Xun |
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| Affiliation: | Department of Anesthesiology, the Affiliated Hospital of JiangHan University, WuHan, 430015, Hubei, China |
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| Abstract: | AIM: To investigate the dose-related effects of ketamine on cumulative survival in mice models of polymicrobial sepsis induced by cecal ligation and puncture (CLP).METHODS: Mice with CLP were divided randomly into four groups, received ketamine injection intraperitoneally of 0, 3, 6, and 12 mg·100 g-1, respectively, at 1 and 6 h after CLP.The survival rate was observed in each group.RESULTS: No change in mortality was observed after 72 hours among four groups.Ketamine administration was associated with significant improvement of the survival of mice with CLP (P<0.05), especially in 6 mg·100 g-1 group (P<0.05).CONCLUSION: Ketamine administration dose-independently delays lethality from sepsis in mice with CLP. |
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| Keywords: | ketamine cecal ligation and puncture sepsis mice cumulative survival |
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