| L-精氨酸可致大鼠正常皮肤皮脂腺增生 |
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| 引用本文： | 尹艳茹,王斐,曹旭. L-精氨酸可致大鼠正常皮肤皮脂腺增生[J]. 金属学报, 2004, 9(9): 1054-1056 |
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| 作者姓名： | 尹艳茹 王斐 曹旭 |
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| 作者单位： | 第一军医大学分校生理学教研室,;1.教保处, 广州510315, 广东 |
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| 摘 要： | 目的: 研究L-精氨酸(L-arg) 对正常皮肤的影响。方法: 用L-arg 给大鼠灌胃, 观察皮肤是否出现病理现象。结果: 10 mg·kg-1 ·d-1 L-arg 灌胃7 d 左右, 雄性成年大鼠组全部动物背部皮肤被毛潮湿、油腻、黄染。成年雌性SD 大鼠组和5 周龄雌性鼠组用药7 d 后被毛光洁白净, 未见背部皮肤被毛潮湿、油腻、黄染, 相同剂量延长用药时间至14 d, 雌性SD成年大鼠组多数动物背部皮肤被毛潮湿、油腻、黄染, 5 周龄雌性鼠组全部动物背部皮肤被毛潮湿、油腻、黄染。停止用药1 周, 大鼠背部皮肤被毛由潮湿、油腻变干爽, 黄染不加重。病理组织图片显示,被毛潮湿、油腻、黄染大鼠的皮肤组织中皮脂腺异常丰富。结论: 小剂量L-arg 可致大鼠正常皮肤皮脂腺增生, 分泌增多, 原因可能是L-arg 及其体内产生的NO 可使大鼠雄激素分泌增多所致。
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| 关 键 词： | L-arg NO 皮脂腺 增生 大鼠 |
| 收稿时间： | 2003-12-05 |
| 修稿时间： | 2004-07-12 |
L-arginine facilitates the hyperplasia of sebaceous gland in rats |
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| YIN Yan-Ru,WANG Fei,CAO Xu. L-arginine facilitates the hyperplasia of sebaceous gland in rats[J]. Acta Metallurgica Sinica, 2004, 9(9): 1054-1056 |
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| Authors: | YIN Yan-Ru WANG Fei CAO Xu |
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| Affiliation: | Department of Physiology,;1.Instrument Ensure Departmentalism, Branch Campus of the First Military Medical University, Guangzhou 510315, Guangdong, China |
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| Abstract: | AIM: To study the effects of L-arginine on sebaceous gland hyperplasia in rats.METHODS: 10 mg·kg-1 ·d-11 of L-arginine was poured into the stomach in Sprague-Dawley rats for 7-14 d. The pathology phenomenon was observed in the rat skin.RESULTS: The backside skin of the male SD rats showed dewiness, greasiness and engrained yellow. The incidence was 100 % for 7 d in the male SD rats, 80 %in the female SD rats for 14 d, but 100 % in the immature female SD rats for 14 d.CONCLUSION: L-arg nine can facilitate the hyperplasia of sebaceous gland in SD rats. |
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| Keywords: | L-arginine nitric oxide sebaceous gland hyperplasia rats |
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