国产重组人粒细胞集落刺激因子在妇科恶性肿瘤化疗中的应用

目的: 探讨不同剂量国产重组人粒细胞集落刺激因子（rhG-CSF)在妇科恶性肿瘤化疗中的疗效,并与进口 rhG-CSF比较。方法: 98例卵巢癌、宫体癌和宫颈癌患者随机分成3组,分别按75 μg·d^-1和150 μg·d^-1剂量皮下注射国产rhG-CSF和进口75 μg·d^-1 rhG-CSF,直到白细胞或中性粒细胞绝对数升至正常水平以上。结果: 不同剂量国产或进口rhG-CSF均能使3组患者血WBC和ANC水平在用药d4后升至正常水平以上;在初次化疗时,用不同剂量（75 μg 和 150 μg）国产和进口（75 μg) rhG-CSF升WBC至正常水平的天数无显著差异（P>0.05),但重复化疗期间150μg国产rhG-CSF升白细胞的疗效显著优于75μg国产或进口 rhG-CSF;同等剂量国产AG-CSF与进口 rhG-CSF升WBC效果一致。结论: 75μg小剂量国产rhG-CSF在妇科恶性肿瘤初期化疗中升WBC的疗效肯定,重复化疗时较大剂量(150μg）rhG-CSF升WBC的效果优于小剂量rhG-CSF。同等剂量国产rhG-CSF与进口 rhG-CSF的疗效无明显差异。

Efficacy of domestic rhG-CSF on leucopenia induced by chemotherapy in patients with gynecological tumors

AIM: To study the effects of different dose of domestic recombinated human granulocyte colony stimulating factor (rhG-CSF) on leucopenia induced by chemotherapy in patients with gynecological tumors. METHODS: 98 patients with gynecological tumors (ovarian cancer 36, endometrial carcinoma 28,cervical cancer 34) were randomly divided into 3 groups. RhG-CSF (domestic) was given at the dose of 75 μg·d^-1, S. C in group A, rhG-CSF (domestic) was given at the dose of 150 μg·d^-1, S. C in group B, and rhG-CSF (import) was given at the dose of 75 μg·d^-1, S. C in group C. RESULTS: The amount of WBC and ANC were in-creased by different dose of domestic rhG-CSF and the im-port rhG-CSF. In first cliemoiherapy, the time when the level of WBC raised higher than 4.0×10⁹ L^-1 were no significant difference among 3 groups (P>0.05). But in repeated chemotherapy, the period of leukopenia recov-ered to normal was shorter in group B than that in group A or group C. The effects of the domestic rhG-CSF on leu-copenia induced by chemotherapy were similar to the im-ported products of same dose. CONCLUSION: Low dose of domestic rhG-CSF (75 μg) can effectively treat the leukopenia caused by postchemotlierapy in patients with gynecological tumors. 150 μg of domestic rhG-CSF is more effective than 75 μg of domestic or import rhG-CSF in treating leukopenia in repeated chemotherapy.