| 大蒜黄酮的分离及抗内毒素活性的评价 |
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| 引用本文： | 蒋栋能,郑江.大蒜黄酮的分离及抗内毒素活性的评价[J].金属学报,2004,9(10):1154-1156. |
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| 作者姓名： | 蒋栋能 郑江 |
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| 作者单位： | 第三军医大学附属西南医院综合实验研究中心, 重庆400038 |
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| 摘 要： | 目的: 筛选和评价大蒜提取成分的抗内毒素作用。方法: 通过离子交换-高效液相色谱等方法从大蒜中筛选出2 个成分(大蒜黄酮1 、2), 采用动态浊度法测定其体外中和内毒素的能力, 观察其对内毒素(20 mg·kg-1)攻击小鼠的保护作用。结果: 大蒜黄酮2 能直接中和内毒素, 对内毒素攻击小鼠有显著的保护作用。结论: 大蒜黄酮2 具有显著的抗内毒素活性。
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| 关 键 词： | 大蒜 黄酮 抗内毒素 活性成分 |
| 收稿时间： | 2004-07-28 |
| 修稿时间： | 2004-08-26 |
Extraction of garlic flavone and its antiendotoxin activity |
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| JIANG Dong-Neng,ZHENG Jiang.Extraction of garlic flavone and its antiendotoxin activity[J].Acta Metallurgica Sinica,2004,9(10):1154-1156. |
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| Authors: | JIANG Dong-Neng ZHENG Jiang |
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| Affiliation: | Medical Research Center, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China |
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| Abstract: | AIM: To extract garlic flavone and evaluate its antiendotoxin activity.METHODS: The two fractions (garlic flavone 1, garlic flavone 2)were screened and extracted by ion exchange-HPLC, and the neutralization ability of the garlic flavone to lipopolysaccharide (LPS)was determined by kinetic turbidimetric assay. The protective effect of the garlic flavone 2 was observed in mice attacked by 20 mg·kg-1 of LPS.RESULTS: The garlic flavone 2 could neutralise LPS and protect mice from the attack of LPS.CONCLUSION: The garlic f lavone 2 has a significant antiendotoxin activity on LPS-attacked mice. |
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| Keywords: | garlic flavone antiendotoxin active fraction |
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