| 表皮生长因子受体酪氨酸激酶抑制剂在肿瘤治疗中的应用 |
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| 引用本文： | 李哲,袁守军. 表皮生长因子受体酪氨酸激酶抑制剂在肿瘤治疗中的应用[J]. 金属学报, 2004, 9(4): 361-364 |
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| 作者姓名： | 李哲 袁守军 |
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| 作者单位： | 军事医学科学院放射医学研究所药理室, 北京100850 |
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| 摘 要： | 表皮生长因子受体(EGFR) 酪氨酸激酶, 是细胞外信号传递到细胞内的重要枢纽, 它在信号传导、细胞增殖、分化以及各种调节机制中发挥重要作用,在多种癌细胞中过度表达。许多研究表明, 抑制EGFR 酪氨酸激酶活性, 可抑制肿瘤生长。目前, 已有几种EGFR 酪氨酸激酶抑制剂进入了临床试验。本文对几种EGFR 酪氨酸激酶小分子抑制剂在肿瘤治疗中的研究进展做一综述。
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| 关 键 词： | 表皮生长因子受体 酪氨酸激酶抑制剂 肿瘤治疗 临床试验 |
| 收稿时间： | 2003-11-26 |
| 修稿时间： | 2003-12-18 |
Application of epidermal growth factor receptor tyrosine kinase inhibitors in cancer therapy |
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| LI Zhe,YUAN Shou-Jun. Application of epidermal growth factor receptor tyrosine kinase inhibitors in cancer therapy[J]. Acta Metallurgica Sinica, 2004, 9(4): 361-364 |
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| Authors: | LI Zhe YUAN Shou-Jun |
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| Affiliation: | Department of Pharmacology, Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850,China |
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| Abstract: | Epidermal growth factor receptor (EGFR) tyrosine kinase is over-expressed in numerous human tumors, which plays pivotal roles in cellular signal transduction, and it is involved in a variety of tumor cellular behaviors such as proliferation, metastasis, angiogenesis and so on.Many investigations have indicated that tumor growth can be suppressed by inhibiting EGFR tyrosine kinase activity.Currently, several EGFR tyrosine kinase inhibitors are in clinical trial stage. |
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| Keywords: | phacology epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors cancer therapy clinical trial |
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