| 高选择性环氧化酶-2 抑制剂罗非昔布对大鼠关节软骨的影响 |
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| 引用本文： | 梁熙,安洪. 高选择性环氧化酶-2 抑制剂罗非昔布对大鼠关节软骨的影响[J]. 金属学报, 2004, 9(3): 312-317 |
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| 作者姓名： | 梁熙 安洪 |
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| 作者单位： | 重庆医科大学附属第一医院骨科, 重庆400016 |
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| 摘 要： | 目的:考察长期服用高选择性环氧化酶-2(COX-2)抑制剂(罗非昔布)对大鼠关节软骨的影响。方法:切除大鼠一侧跟腱, 造成膝关节骨关节病的早期模型, 非手术侧为正常对照。大鼠随机分成2 组, 一组灌胃给药, 另一组生理盐水灌胃作对照。用药100 d 后, 对关节软骨进行组织学、超微结构观察和组织化学定量分析。结果:罗非昔布长期服用,对骨关节病及非骨关节病的软骨细胞、胶原代谢无不良影响, 在一定程度上可增加软骨蛋白多糖的含量。结论:长期服用罗非昔布对大鼠关节软骨无不良影响。
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| 关 键 词： | 非甾体抗炎药 关节软骨 骨关节病 罗非昔布 蛋白多糖 软骨细胞 |
| 收稿时间： | 2003-08-10 |
| 修稿时间： | 2003-11-03 |
Influence of rofecoxib,a high selective cox-2 inhibitor,on articular cartilage of rats |
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| LIANG Xi,AN Hong. Influence of rofecoxib,a high selective cox-2 inhibitor,on articular cartilage of rats[J]. Acta Metallurgica Sinica, 2004, 9(3): 312-317 |
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| Authors: | LIANG Xi AN Hong |
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| Affiliation: | Department of Orthopedic Surgery, the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China |
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| Abstract: | AIM: To observe the influence of rofecoxib, a non-steroidal anti-inf lammatory drug, administrated for a long term on the knee joints cartilage of rats. METHODS: An experimental model of osteoarthritis of left knee in the early stage was induced by cutting achilles tendon in rats, the right knee providing a control.The rats of one group were given rofecoxib orally, and the rats in another group were given saline as a control.After 100 days, the histopathology, ultrastructure, and histochemistry changes on the knee joints cartilage were monitored. RESULTS and CONCLUSION: Rofecoxib, administrated for 100 days, had no harmful influence on chondrocyte and collagen, and could increase proteoglycan of cartilage in some degree in rats. |
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| Keywords: | non-steroid anti-inflammatory drugs (NSAIDs) cartilage osteoarthritis rofecoxib proteoglycan chondrocyte |
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