去甲肾上腺素对幼犬股骨头血流量的影响

目的: 观察去曱肾上腺素对髋关节引起的病理变化,探讨髋关节一过性滑膜炎的发病机理。方法: 40只2~3月大小的幼狗,随机分为10组,分别在髋关节内注入2‰去甲腎上腺素,在不同时间用"ni锝亚甲基二磷酸盐（^99mTC-MDP)三相骨显像,观察股骨头局部循环血流变化,同时测定关节内压变化、病理组织学检查,观察整个髋关节的病理变化及发展过程。结果: 注入2‰知去甲肾上腺素引起股骨头局部血管短暂收缩,血流量下降,3 h后小血管扩张、充血、滑膜水肿,关节渗出,关节内压升高,血流量下降,持续2周左右,4周后逐渐恢复正常,无滑膜、股骨头坏死。整个过程表现与髋关节一过性滑膜炎临床表现极为相似。结论: 2‰去甲肾上腺素可引起小血管扩张、充血、滑膜水肿,关节渗出,关节内压升高导致股骨头局部一过性缺血,产生与髋关节一过性滑膜炎临床表现极为相似的炎性反应。去甲肾上腺素在髋关节一过性滑膜炎发病机理中可能起重要的作用。

Effects of noradrenaline on blood supply of femoral head in dogs

AIM: To observe the changes of the hip in means of injecting 2‰ noradrenaline (NA) into the hip joint cavity and study the pathogenesis of transient sy-novitis of hip. METHODS: Forty 2-3 months old dogs were divided into 10 groups,and 2‰ NA was injected into the hip joint. ^99mTC-MDP triphasic imaging was used to observe the local blood supply of femoral head, intra-articular pressure was determined, and patholoyical changes were observed to understand the natural course of the disease process. RESULTS: Injecting 2‰ noradrena-line resulted in transient contraction of blood vessels in femoral head and after 3 hours blood vessels begun to ex-pand, exudation of hip joint caused an increase of pressure in hip joint. This process continued for 2 weeks. There was no necrosis of synovium and femoral head. The whole process resembled transient synovitis of hip in the clinical manifestation. CONCLUSION: Injecting 2‰ noradrenaline results in extension and congestion of hlood vessels. An increase of pressure in hip joint causes tran-sient ischemia in femoral head. The whole process resem-hles transient synovitis of hip in the clinical manifesta-tion.Noradrenaline may play an important role in the pathogenesis of transient synovitis of hip.