| 老年性痴呆动物模型及其评价 |
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| 引用本文： | 王颖彦,黄韧,王晖. 老年性痴呆动物模型及其评价[J]. 金属学报, 2004, 9(3): 249-252 |
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| 作者姓名： | 王颖彦 黄韧 王晖 |
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| 作者单位： | 广东医学院药理教研室, 湛江524023, 广东;1.广东省实验动物监测所, 广州510260, 广东 |
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| 基金项目： | 广东省自然科学基金重点项目(№010086) |
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| 摘 要： | 老年性痴呆(Alzheimer's disease, AD)是一种神经退行性疾病, 其动物模型的建立对于AD 的防治研究起重要作用。虽然AD 动物模型的研究取得了阶段性的进展, 但一个理想的动物模型的制作, 仍需要做大量的工作。本文对AD 各类动物模型的研究现状进行综述, 并对各类动物模型的优劣进行评价。
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| 关 键 词： | 老年性痴呆 动物模型 转基因动物 早衰小鼠 神经原纤维缠结 老年斑 淀粉样蛋白 |
| 收稿时间： | 2003-08-11 |
| 修稿时间： | 2003-11-20 |
Animal models of Alzheimer's disease and their evaluation |
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| WANG Ying-Yan,HUANG Ren,WANG Hui. Animal models of Alzheimer's disease and their evaluation[J]. Acta Metallurgica Sinica, 2004, 9(3): 249-252 |
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| Authors: | WANG Ying-Yan HUANG Ren WANG Hui |
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| Affiliation: | Department of Pharmacology, Guangdong Medical College, Zhanjiang 514023, Guangdong, China;1.Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510260,Guangdong, China |
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| Abstract: | Alzheimer's disease (AD)is a kind of disease in nervous system.A good models is very important in the research of prevention and remedy.The present progress of these models were reviewed, and the merits and defeats were evaluated.The researches of AD have acquired a few of staged achievements, but no critical breakthrough.The road leads to perfect models is long still. |
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| Keywords: | Alzheimer's disease disease model transgenic animals senescence accelerated mouse neuronfibrillary tangles senile plague amyliod protein |
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