| 重组人组织型纤溶酶原激活剂缺失变体对家兔纤溶和凝血系统活性的影响 |
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| 引用本文： | 董六一,范丽,江勤,方明,岑德意,陈飞虎,智强,陈志武.重组人组织型纤溶酶原激活剂缺失变体对家兔纤溶和凝血系统活性的影响[J].金属学报,2004,9(7):778-780. |
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| 作者姓名： | 董六一 范丽 江勤 方明 岑德意 陈飞虎 智强 陈志武 |
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| 作者单位： | 安徽医科大学药理教研室, ;1.药学系, 合肥230032, 安徽;2.桑尼生物技术研究所, 合肥230042, 安徽 |
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| 摘 要： | 目的: 观察重组人组织型纤溶酶原激活剂缺失变体(reteplase,Ret)对家兔纤溶和凝血系统活性的影响。方法: 采用常规方法测定家兔血液纤溶和凝血系统相关参数指标。结果: Ret (3.75、7.50、15.0 MIU·kg-1)可明显降低纤溶酶原含量,使血浆纤维蛋白降解产物转呈阳性反应,缩短优球蛋白溶解时间,同时延长血浆凝血酶时间,凝血酶原时间及活化部分凝血活酶时间。结论: Ret 可促进血液纤溶系统活性和抑制凝血系统活性。
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| 关 键 词： | 重组人组织型纤溶酶原激活剂缺失变体 组织型纤溶酶原激活剂 纤溶系统 凝血系统 家兔 |
| 收稿时间： | 2004-04-05 |
| 修稿时间： | 2004-05-18 |
Effects of reteplase on fibrinolytic and coagulation systems in rabbits |
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| DONG Liu-Yi,FAN Li,CHEN Zhi-Wu,JIANG Qin,FANG Ming,CEN De-Yi,CHEN Fei-Hu,ZHI Qiang.Effects of reteplase on fibrinolytic and coagulation systems in rabbits[J].Acta Metallurgica Sinica,2004,9(7):778-780. |
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| Authors: | DONG Liu-Yi FAN Li CHEN Zhi-Wu JIANG Qin FANG Ming CEN De-Yi CHEN Fei-Hu ZHI Qiang |
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| Affiliation: | Department of Pharmacology, ;1.Department of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China;2.Sangni Institute of Biotechnology, Heifei 230042, Anhui, China |
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| Abstract: | AIM: To investigate the effects of reteplase (Ret) on fibrinolytic and coagulation systems in rabbits.METHODS: The relative parameters of blood coagulation system and fibrinolytic systems were measured.RESULTS: Ret (3.75, 7.50, 15.0MIU·kg-1) lessened the content of plasminogen (Plg) and promoted the plasma fibrinogen degradation product (FDP) significantly, shortened plasma euglobulin lysis time (ELT), prolonged plasma thrombin time (TT), prothrombin time (PT), and active partial thromboplastin time (APTT).CONCLUSION: Ret can promote fibrinolytic system function and inhibit blood coagulation system function. |
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| Keywords: | reteplase tissue-type plasminogen activator fibrinolytic system coagulation system rabbits |
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