| 细胞色素P450 与药物代谢的研究现状 |
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| 引用本文： | 朱立勤,娄建石. 细胞色素P450 与药物代谢的研究现状[J]. 金属学报, 2004, 9(10): 1081-1086 |
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| 作者姓名： | 朱立勤 娄建石 |
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| 作者单位： | 天津医科大学药理教研室, 天津300070 |
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| 摘 要： | 细胞色素P450(CYP)在众多中西药物代谢中起着非常重要的作用。本文综述了与药物代谢相关的CYP 亚型、CYP 与药物相互作用的关系及中药对CYP 的影响, 旨在合理解释和预测临床上药物间相互作用和药物不良反应等。同时选择适当的药物作为探针来评价CYP 的活性, 为实现临床个体化给药提供科学依据。
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| 关 键 词： | 细胞色素P450 中药 药物相互作用 药物代谢 |
| 收稿时间： | 2004-08-04 |
| 修稿时间： | 2004-09-16 |
Resent studies on cytochrome P450 and drug metabolism |
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| ZHU Li-Qin,LOU Jian-Shi. Resent studies on cytochrome P450 and drug metabolism[J]. Acta Metallurgica Sinica, 2004, 9(10): 1081-1086 |
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| Authors: | ZHU Li-Qin LOU Jian-Shi |
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| Affiliation: | Department of Pharmacology, Tianjin Medical University, Tianjin 300070, China |
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| Abstract: | Cytochrome P450 is one of the important drug metabolization enzymes in humans. This paper reviews drug-relevant CYP, the relationship of CYP and drug interaction, and effects of Chinese medicine on CYP. The aim is to answer and predict the clinical drug interaction and the adverse drug reactions. Moreover, suitable drug can be selected to evaluate the action of CYP, and it can offer the scientific assurance for clinical individual therapy. |
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| Keywords: | cytochrome P450 Chinese medicine drug interaction drug metabolism |
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