| 177Lu-EDTMP和177Lu-DOTMP的标记研究及骨靶向评价对比 |
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| 引用本文： | 邓新荣,李凤林,李洪玉,叶肇云,罗志福. 177Lu-EDTMP和177Lu-DOTMP的标记研究及骨靶向评价对比[J]. 同位素, 2009, 22(2): 0 |
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| 作者姓名： | 邓新荣 李凤林 李洪玉 叶肇云 罗志福 |
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| 作者单位： | 中国原子能科学研究院 |
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| 摘 要： | 用于肿瘤治疗的177Lu标记的放射性药物是当今核医学研究中的一个热点，多齿氨甲基膦酸与多种发射 -粒子的核素都能形成良好的配合物，而且已被证明可以有效的治疗骨转移癌疼痛。177Lu-EDTMP和177Lu-DOTMP有可能应用于骨转移癌疼痛的治疗。本文研究了177Lu对 EDTMP和DOTMP的标记，并对标记物的靶向性进行了初步的研究，进行了正常动物体内生物分布和显像的研究。
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| 关 键 词： | EDTMP DOTMP 177Lu 骨转移癌疼痛 |
| 收稿时间： | 2008-12-09 |
Radiolabeling and Comparative studies of 177Lu-EDTMP and 177Lu-DOTMP |
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| Abstract: | The study of 177Lu labeled radiopharmaceuticals for cancer therapy is fast emerging as an important part of nuclear medicine. Multidentate aminomethylenephosphonic acids could form well-characterized stable complexes with different β- emitting radionuclides and have already proven to be very effective for palliation of bone pain. 177Lu-EDTMP and 177Lu-DOTMP are possible to be effective radiopharmaceuticals for pain palliation due to bone cancer. At present, the labeling methods for 177Lu-EDTMP and 177Lu-DOTMP are established. The biodistributiion of 177Lu-EDTMP and 177Lu-DOTMP in normal mice is carried out as well. |
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| Keywords: | EDTMP DOTMP 177Lu bone cancer pain |
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